Cellular metabolism
Cellular metabolism orchestrates the supply of resources and energy needed for the diversity of cellular functions, including protein synthesis, cellular growth and motility. Therefore, quantifying metabolic activities within individual cells in tissues is essential for understanding their physiological roles and potential alterations in aging and diseases. Additionally mapping these metabolic activities spatially within tissues is vital for insights into how cells work synergistically to perform complex tasks and how these functions change in disease states. By leveraging metabolic modeling with novel strategies to understand metabolism from genomics data, I aim to elucidate how metabolic activities help to perform cellular functions, shaping phenotypes under different biological conditions.
I have been developing computational approaches to study metabolism by:
- Applying metabolic modeling based on flux balance analysis.
- Adapting CellFie and adding new capabilities to study metabolism with single-cell and spatial resolution.
- Using AI to understand metabolism from multiple modalities.
- Analyzing the whole Human Cell Atlas to reveal underexplored metabolic insights across tissues.
